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KMID : 0364320170420020033
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Journal of East-West Medicine
2017 Volume.42 No. 2 p.33 ~ p.42
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Effects of Phyllostachys folium water extracts on the carrageenan-induced acute inflammation in rats: histological aspects
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Son Jin-Won
Jee Seon-Young
Park Chung-A
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Abstract
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Phyllostachys folium is leaves of Phyllostachys nigra (Lodd.) Munro var. henonis (Bean) Stapf. The effects of Phyllostachys folium water extract (PFE) on the carrageenan (CA) -induced acute edematous inflammation were observed by histopathological methods. The changes on the histopathology and histomorphometry of hind paw skins were observed in CA-treated rats as changes on the total skin thicknesses, infiltrated inflammatory and mast cell numbers. Marked increases of the dorsum and ventrum pedis skin thicknesses were detected as results of CA induced acute edematous inflammation on CA-treated rats as compared with intact control rat paw skins, and marked degranulation-related decreases of mast cell numbers, increases of infiltrated inflammatory cell numbers were also noticed on the both dorsum and ventrum pedis cutaneous regions in CA-treated rats, respectively. However, these CA-induced acute edematous inflammatory changes and degranulation-related decreases of mast cells were significantly inhibited by treatment with DEXA and PFE 1.0 g/㎏, respectively. Although PFE 0.3 g/㎏ treated rat paw did not show significant changes on the skin thicknesses, it significantly inhibited the inflammatory cell infiltration and mast cell degranulation on the both dorsum and ventrum pedis skin as compared with CA control rats.
In conclusion, it is considered that PFE 1.0 g/㎏ inhibits the acute edematous inflammation via suppression of mast cell degranulation and inflammatory cell infiltration, because PFE 1.0 g/㎏ favorably inhibited the CA-induced increases of skin thicknesses, mast cell degranulation, and infiltrated inflammatory cells, respectively. PFE 0.3 g/㎏ did not show any significant changes on the edematous increases of skin thicknesses, but it significantly inhibited inflammatory cell infiltration and mast cell degranulation as compared with CA control rats.
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KEYWORD
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Phyllostachys folium, Inflammation, Histopathology
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